Talks

2020

Use of multistate models to improve decision-making in clinical trials
Dec 9, 2020 09:15
Seminar, Vienna Biometric Section (invited talk)
Estimands update: Summary of world-wide authority interaction
Nov 27, 2020 00:00
Meeting of the Working Group Pharmaceutical Research of the German Region of the IBS
A deep dive into principal stratification and causal inference
Nov 17, 2020 00:00
Effective statistician podcast (invited discussion jointly with Björn Bornkamp)
Use of multistate models to improve decision-making in clinical trials
Oct 21, 2020 11:00
Seminar, Department of Mathematics, University of Basel (invited talk)
PSI Conference Webinar: Impact of COVID-19 to estimands
Jun 11, 2020 15:30
PSI webinar (invited talk)
Slides
Panel discussion: estimands in oncology
May 21, 2020 17:00
Virtual panel discussion (invited talk)
Slides Video
Use of multistate models to improve decision-making in clinical trials
Feb 28, 2020 16:15
University of Zurich / ETH applied statistics seminar (invited talk)
A statistician's view on complex innovative designs
Feb 25, 2020 10:15
Workshop Complex Adaptive Clinical Trials swissethics - Swissmedic (invited talk)

2019

Use of multistate models to jointly model progression-free and overall survival and improve decision-making in clinical trials
Nov 14, 2019 14:00
Seminar, MRC Biostatistics Unit, Cambridge University (invited talk)
Slides
Implications of the ICH E9 estimand addendum on how we develop, run, and analyze clinical trials
Oct 16, 2019 11:25
Clinical Trials Europe (invited talk)
Slides
Before going BIG - seize opportunities for small data: use of multistate models to improve decision-making and effect quantification in clinical trials
Sep 10, 2019 15:10
Conference of the Austro-Swiss Region of the IBS (invited talk)
PDF Slides Code
rpact - R Package for Adaptive Clinical Trials
Jul 4, 2019 15:00
PSI webinar (invited talk)
Slides
Multistate models to improve decision-making and effect quantification in clinical trials
Jun 27, 2019 00:00
Shanghai Biostatistics Forum (invited talk)
Estimand framework in Oncology drug development – impact and opportunities
Jun 4, 2019 00:00
PSI annual conference (contributed talk)
Bayesian Predictive Power: Theory, challenges in implementation, and perspectives
May 23, 2019 00:00
Bayesian Biostatistics Conference (bayes-pharma, invited talk)
PDF
External controls in drug development (with Hans Ulrich Burger)
May 10, 2019 00:00
Spring seminar of the Basel Biometric Section (invited talk)
PDF
MIRROS: Phase 3 trial with time-to-event endpoint, cure proportion, and futility interim analysis using response
Apr 2, 2019 00:00
SMi conference on adaptive clinical trials (invited talk)
Slides
Estimand framework in Oncology drug development -- impact and opportunities
Mar 19, 2019 00:00
Annual Meeting of the International Biometric Society, German Region (contributed talk delivered by Bjoern Bornkamp)

2018

Univariate log-concave density estimation and more efficient treatment effect estimation in pre-specified subgroups displayed in forest plots for time-to-event outcomes
Nov 22, 2018 00:00
Statistics seminar, University of Bochum (invited talk)
MIRROS: Planning a Phase 3 trial with time-to-event endpoint, a cure proportion, and a futility interim analysis using response
Oct 23, 2018 00:00
Oncology workshop, University of Heidelberg (invited talk)
Randomization and External Controls - When to Use What in a Drug Development Landscape
Oct 18, 2018 00:00
Roche RxDx summit (invited talk)
Assess Common Surrogate Endpoints in Lymphoma using a Multistate Model
Oct 17, 2018 00:00
Roche Global Biostatistics Conference (contributed talk)
More efficient treatment effect estimation in pre-specified subgroups displayed in forest plots for time-to-event outcomes
Oct 4, 2018 00:00
Workshop on Adaptive Designs and Multiple Testing Procedures (contributed talk)
Immortal bias - you live longer if you cannot die
Sep 10, 2018 00:00
Modeling and Simulation seminar (invited talk)
Slides
Overall survival prediction conditional on post-randomization events: multistate models, landmark analyses, and others
Jun 21, 2018 00:00
Seminar Biostatistics group Boehringer-Ingelheim (invited talk)
The Estimand Framework Applied to Time-to-event Endpoints
Mar 28, 2018 00:00
Annual Meeting of the International Biometric Society, German Region (contributed talk)
Estimands and the ICH E9 draft addendum
Feb 13, 2018 00:00
Special Colloquia Epidemiology, Biostatistics, and Prevention Institute, University of Zurich (invited talk)

2017

Treatment effect measures for time-to-event endpoints - estimands, analysis strategies, and beyond
Nov 24, 2017 00:00
Meeting of the Working Group Pharmaceutical Research of the German Region of the IBS (invited talk)
Construction of an Estimand in a Clinical Trial on Progressive Multiple Sclerosis
Oct 4, 2017 00:00
2nd EFSPI Regulatory Statistics Workshop (invited talk)
PDF
Evolvement of assurance over the lifecycle of several Phase 3 trials in a large oncology clinical development program
Aug 31, 2017 00:00
Joint Meeting of the International Biometric Society Austro-Swiss, German, and Polish Region (invited talk)
Joint modelling of progression-free and overall survival
Jul 12, 2017 00:00
Annual Conference of the International Society for Clinical Biostatistics (contributed talk)
Treatment effect measures for time-to-event endpoints - Estimands and beyond
Jun 13, 2017 00:00
Workshop on Innovation in Oncology Clinical Trial Design, organized by the Cancer Drug Development Forum (invited talk)
PDF
Comparison of clinical development plans for a confirmatory trial with subpopulation selection
Mar 13, 2017 00:00
Seminar, Basel Biometric Section of the IBS (invited talk)
PDF

2016

Bayesian Predictive Power: update after a blinded interim analysis and choice of update after a blinded interim analysis and choice of prior
Dec 12, 2016 00:00
Statistics Seminar, Institute for Medical Biometry, University of Heidelberg (invited talk)
Estimands for time to event endpoints
Nov 14, 2016 00:00
European Statistical Forum (invited talk)
Bayesian Predictive Power: update after a blinded interim analysis and choice of prior
Nov 10, 2016 00:00
Statistics Seminar, Institute for Social and Preventive Medicine, University of Lausanne (invited talk)
Estimands for time to event endpoints in oncology and beyond
Sep 12, 2016 00:00
1st EFSPI Regulatory Statistics Workshop (invited talk, delivered by Uli Burger)
PDF
Bayesian Predictive Power: Choice of Prior and some implications
Aug 23, 2016 00:00
Annual Conference of the International Society for Clinical Biostatistics (contributed talk)
Bayesian Predictive Power: Choice of Prior and some Recommendations for its Use as Probability of Success in Drug Development
May 24, 2016 00:00
PSI annual conference (contributed talk delivered by Markus Abt)
Time to think about estimands for time-to-event endpoints? A few examples
May 24, 2016 00:00
PSI conference (invited talk, delivered by Uli Burger)
Event projection: quantify uncertainty and manage expectations of broader teams
Apr 28, 2016 00:00
Seminar, Basel Biometric Section of the IBS (invited talk)
PDF
Bayesian Predictive Power: Choice of Prior and some Recommendations for its Use as Probability of Success in Drug Development
Mar 2, 2016 00:00
Statistics Seminar, University of Ulm (invited talk)

2015

A Weibull Regression Model for a Time-to-Event Endpoint with an Interval-Censored Covariate and its Application in Assessing Prentice's Criteria for Surrogacy
Nov 20, 2015 00:00
3rd BIMIT (Verbundprojekt Biostatistische Methoden zur effizienten Evaluation von Individualisierten Therapien) workshop (invited talk)
Bayesian Predictive power: the bathtub phenomenon
Oct 27, 2015 00:00
Seminar, Basel Biometric Section of the IBS (invited talk)
Comparison of clinical development plans for a confirmatory trial with subpopulation selection
Jun 18, 2015 00:00
Joint Meeting of the International Biometric Society Austro-Swiss and Italian Regions (invited talk)
Evaluation of possible designs for a three-arm clinical trial: Comparing a closed-testing design to potential alternatives
Jun 16, 2015 00:00
Joint Meeting of the International Biometric Society Austro-Swiss and Italian Regions (contributed talk)
Evaluation of possible designs for a three-arm clinical trial: Comparing the CLL11 design to potential alternative designs
May 20, 2015 00:00
Roche Global Biostatistics Conference (contributed talk)
Bayesian predictive power: update after a blinded interim and fallacies
Apr 17, 2015 00:00
Seminar, Institute for Mathematical Statistics and Actuarial Science, University of Bern (invited talk)

2014

How good is your biomarker? Comparison of development plans for confirmatory biomarker enrichment
Nov 20, 2014 00:00
2nd BIMIT (Verbundprojekt Biostatistische Methoden zur effizienten Evaluation von Individualisierten Therapien) workshop (invited talk)
How good is your biomarker? Comparison of development plans for confirmatory biomarker enrichment
Nov 11, 2014 00:00
Joint DIA/AEMPS Statistics Workshop (invited talk)
How statistics can contribute to innovative trials
Sep 18, 2014 00:00
2nd Symposium for the RxDx Generation, Roche (invited talk)
Weibull Regression for a Right-Censored Endpoint with a Censored Covariate
Aug 28, 2014 00:00
Annual Conference of the International Society for Clinical Biostatistics (contributed talk)
Update Bayesian predictive power after a blinded interim analysis
Jul 2, 2014 00:00
Bayesian Biostatistics 2014 - Satellite conference of the International Biometric Conference (contributed talk)
Update Bayesian predictive power after a blinded interim analysis
Mar 27, 2014 00:00
University of Zurich / ETH applied statistics seminar (invited talk)

2013

Update Bayesian Predictive Power after a blinded interim analysis
Oct 23, 2013 00:00
Roche Global Biostatistics Conference (contributed talk)

2011

A smooth ROC curve estimator based on log-concave density estimates
Sep 13, 2011 00:00
Conference of the Central European Network of the International Biometric Society (CEN 2011, contributed talk)
Selection models with monotone weight functions in meta analysis
Jun 21, 2011 00:00
Methods in Meta Analysis Meeting (contributed talk)

2010

Ordered Monotone Regression
Aug 3, 2010 00:00
Joint Statistical Meetings (contributed talk)
Proposal of the vote of thanks in discussion of Cule, M., Samworth, R., and Stewart, M.: Maximum likelihood estimation of a multidimensional logconcave density
May 12, 2010 00:00
Research Section Meeting Royal Statistical Society (invited talk)
Ordered Monotone Regression
Mar 2, 2010 00:00
German Open Conference on Probability and Stochastics (contributed talk)
Score regression: a new approach to assess calibration of continuous probabilistic predictions
Jan 26, 2010 00:00
Workshop Statistical Issues in Prediction: What can be Learned for Individualized Predictive Medicine? (invited talk)
Ordered monotone regression
Jan 12, 2010 00:00
Seminar, Basel Biometric Section of the IBS (invited talk)

2009

Regularized regression models in R
Feb 11, 2009 00:00
Department of Neurology and Neurological Sciences, Stanford University School of Medicine (invited talk)

2008

On a new approach to regression models with ordinal explanatory variables
Mar 12, 2008 00:00
Conference of the Central European Network of the International Biometric Society (Lifestat 2008, contributed talk)
A general criterion for multiscale inference
Jan 17, 2008 00:00
Seminar, Basel Biometric Section of the IBS (invited talk)

2007

Nonparametric Estimation of Log-Concave Densities
Dec 8, 2007 00:00
Seminar, Institute for Stochastics, University of Karlsruhe (invited talk)
A general criterion for multiscale inference
Sep 28, 2007 00:00
Seminar, Institute for Mathematical Statistics and Actuarial Science, University of Bern (invited talk)
Predicting Alzheimer from proteomic blood markers
Sep 13, 2007 00:00
Basel Institute for Clinical Epidemiology, University of Basel (invited talk)
On a new approach to regression with ordered explanatory variables
Sep 11, 2007 00:00
Conference of the Austro-Swiss Region of the IBS (contributed talk)
Max-domain of attraction for log-concave densities and smooth tail index estimation
Jul 31, 2007 00:00
Seminar, Statistics Department, Stanford University (invited talk)

2006

The log-concave density estimator as a smoother
Nov 11, 2006 00:00
Workshop Qualitative Assumptions and Regularization in High-Dimensional Statistics (invited talk)
Smoothed semi-parametric tail index estimation and max-domain of attraction for log-concave densities
Mar 15, 2006 00:00
German Open Conference on Probability and Stochastics (contributed talk)

2005

Log-concave density estimation
Aug 23, 2005 00:00
Seminar, Statistics Department, Stanford University (invited talk)
Log-concave density estimation
Jul 27, 2005 00:00
European Meeting of Statisticians (contributed talk)
Log-concave density estimation and bump hunting
Jul 19, 2005 00:00
European Young Statisticians Training Camp (contributed talk)

2004

Log-concave density estimation and uniform rate of convergence
Mar 26, 2004 00:00
German Open Conference on Probability and Stochastics (contributed talk)

2003

Computing maximum likelihood estimators of log-concave densities
Aug 6, 2003 00:00
Joint Statistical Meetings (contributed talk)