Talks

Virtual Regulator - Pharma Industry Forum: Statistical Considerations in Future Oncology Trials, organized by the American Statistical Association Biopharmaceutical Section (invited talk)

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2020

Use of multistate models to improve decision-making in clinical trials

Dec 9, 2020 09:15

Seminar, Vienna Biometric Section (invited talk)

Slides

Estimands update: Summary of world-wide authority interaction

Nov 27, 2020 00:00

Meeting of the Working Group Pharmaceutical Research of the German Region of the IBS

A deep dive into principal stratification and causal inference

Nov 17, 2020 00:00

Effective statistician podcast (invited discussion jointly with Björn Bornkamp)

Video

Use of multistate models to improve decision-making in clinical trials

Oct 21, 2020 11:00

Seminar, Department of Mathematics, University of Basel (invited talk)

PSI Conference Webinar: Impact of COVID-19 to estimands

Jun 11, 2020 15:30

PSI webinar (invited talk)

Slides

Panel discussion: estimands in oncology

May 21, 2020 17:00

Virtual panel discussion (invited talk)

Slides Video

Use of multistate models to improve decision-making in clinical trials

Feb 28, 2020 16:15

University of Zurich / ETH applied statistics seminar (invited talk)

A statistician's view on complex innovative designs

Feb 25, 2020 10:15

Workshop Complex Adaptive Clinical Trials swissethics - Swissmedic (invited talk)

2019

Use of multistate models to jointly model progression-free and overall survival and improve decision-making in clinical trials

Nov 14, 2019 14:00

Seminar, MRC Biostatistics Unit, Cambridge University (invited talk)

Slides

Implications of the ICH E9 estimand addendum on how we develop, run, and analyze clinical trials

Oct 16, 2019 11:25

Clinical Trials Europe (invited talk)

Slides

Before going BIG - seize opportunities for small data: use of multistate models to improve decision-making and effect quantification in clinical trials

Sep 10, 2019 15:10

Conference of the Austro-Swiss Region of the IBS (invited talk)

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rpact - R Package for Adaptive Clinical Trials

Jul 4, 2019 15:00

PSI webinar (invited talk)

Slides

Multistate models to improve decision-making and effect quantification in clinical trials

Jun 27, 2019 00:00

Shanghai Biostatistics Forum (invited talk)

Estimand framework in Oncology drug development – impact and opportunities

Jun 4, 2019 00:00

PSI annual conference (contributed talk)

Bayesian Predictive Power: Theory, challenges in implementation, and perspectives

May 23, 2019 00:00

Bayesian Biostatistics Conference (bayes-pharma, invited talk)

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External controls in drug development (with Hans Ulrich Burger)

May 10, 2019 00:00

Spring seminar of the Basel Biometric Section (invited talk)

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MIRROS: Phase 3 trial with time-to-event endpoint, cure proportion, and futility interim analysis using response

Apr 2, 2019 00:00

SMi conference on adaptive clinical trials (invited talk)

Slides

Estimand framework in Oncology drug development -- impact and opportunities

Mar 19, 2019 00:00

Annual Meeting of the International Biometric Society, German Region (contributed talk delivered by Bjoern Bornkamp)

2018

Univariate log-concave density estimation and more efficient treatment effect estimation in pre-specified subgroups displayed in forest plots for time-to-event outcomes

Nov 22, 2018 00:00

Statistics seminar, University of Bochum (invited talk)

MIRROS: Planning a Phase 3 trial with time-to-event endpoint, a cure proportion, and a futility interim analysis using response

Oct 23, 2018 00:00

Oncology workshop, University of Heidelberg (invited talk)

Randomization and External Controls - When to Use What in a Drug Development Landscape

Oct 18, 2018 00:00

Roche RxDx summit (invited talk)

Assess Common Surrogate Endpoints in Lymphoma using a Multistate Model

Oct 17, 2018 00:00

Roche Global Biostatistics Conference (contributed talk)

More efficient treatment effect estimation in pre-specified subgroups displayed in forest plots for time-to-event outcomes

Oct 4, 2018 00:00

Workshop on Adaptive Designs and Multiple Testing Procedures (contributed talk)

Immortal bias - you live longer if you cannot die

Sep 10, 2018 00:00

Modeling and Simulation seminar (invited talk)

Slides

Overall survival prediction conditional on post-randomization events: multistate models, landmark analyses, and others

Jun 21, 2018 00:00

Seminar Biostatistics group Boehringer-Ingelheim (invited talk)

The Estimand Framework Applied to Time-to-event Endpoints

Mar 28, 2018 00:00

Annual Meeting of the International Biometric Society, German Region (contributed talk)

Estimands and the ICH E9 draft addendum

Feb 13, 2018 00:00

Special Colloquia Epidemiology, Biostatistics, and Prevention Institute, University of Zurich (invited talk)

2017

Treatment effect measures for time-to-event endpoints - estimands, analysis strategies, and beyond

Nov 24, 2017 00:00

Meeting of the Working Group Pharmaceutical Research of the German Region of the IBS (invited talk)

Construction of an Estimand in a Clinical Trial on Progressive Multiple Sclerosis

Oct 4, 2017 00:00

2nd EFSPI Regulatory Statistics Workshop (invited talk)

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Evolvement of assurance over the lifecycle of several Phase 3 trials in a large oncology clinical development program

Aug 31, 2017 00:00

Joint Meeting of the International Biometric Society Austro-Swiss, German, and Polish Region (invited talk)

Joint modelling of progression-free and overall survival

Jul 12, 2017 00:00

Annual Conference of the International Society for Clinical Biostatistics (contributed talk)

Treatment effect measures for time-to-event endpoints - Estimands and beyond

Jun 13, 2017 00:00

Workshop on Innovation in Oncology Clinical Trial Design, organized by the Cancer Drug Development Forum (invited talk)

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Comparison of clinical development plans for a confirmatory trial with subpopulation selection

Mar 13, 2017 00:00

Seminar, Basel Biometric Section of the IBS (invited talk)

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2016

Bayesian Predictive Power: update after a blinded interim analysis and choice of update after a blinded interim analysis and choice of prior

Dec 12, 2016 00:00

Statistics Seminar, Institute for Medical Biometry, University of Heidelberg (invited talk)

Estimands for time to event endpoints

Nov 14, 2016 00:00

European Statistical Forum (invited talk)

Bayesian Predictive Power: update after a blinded interim analysis and choice of prior

Nov 10, 2016 00:00

Statistics Seminar, Institute for Social and Preventive Medicine, University of Lausanne (invited talk)

Estimands for time to event endpoints in oncology and beyond

Sep 12, 2016 00:00

1st EFSPI Regulatory Statistics Workshop (invited talk, delivered by Uli Burger)

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Bayesian Predictive Power: Choice of Prior and some implications

Aug 23, 2016 00:00

Annual Conference of the International Society for Clinical Biostatistics (contributed talk)

Bayesian Predictive Power: Choice of Prior and some Recommendations for its Use as Probability of Success in Drug Development

May 24, 2016 00:00

PSI annual conference (contributed talk delivered by Markus Abt)

Time to think about estimands for time-to-event endpoints? A few examples

May 24, 2016 00:00

PSI conference (invited talk, delivered by Uli Burger)

Event projection: quantify uncertainty and manage expectations of broader teams

Apr 28, 2016 00:00

Seminar, Basel Biometric Section of the IBS (invited talk)

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Bayesian Predictive Power: Choice of Prior and some Recommendations for its Use as Probability of Success in Drug Development

Mar 2, 2016 00:00

Statistics Seminar, University of Ulm (invited talk)

2015

A Weibull Regression Model for a Time-to-Event Endpoint with an Interval-Censored Covariate and its Application in Assessing Prentice's Criteria for Surrogacy

Nov 20, 2015 00:00

3rd BIMIT (Verbundprojekt Biostatistische Methoden zur effizienten Evaluation von Individualisierten Therapien) workshop (invited talk)

Bayesian Predictive power: the bathtub phenomenon

Oct 27, 2015 00:00

Seminar, Basel Biometric Section of the IBS (invited talk)

Comparison of clinical development plans for a confirmatory trial with subpopulation selection

Jun 18, 2015 00:00

Joint Meeting of the International Biometric Society Austro-Swiss and Italian Regions (invited talk)

Evaluation of possible designs for a three-arm clinical trial: Comparing a closed-testing design to potential alternatives

Jun 16, 2015 00:00

Joint Meeting of the International Biometric Society Austro-Swiss and Italian Regions (contributed talk)

Evaluation of possible designs for a three-arm clinical trial: Comparing the CLL11 design to potential alternative designs

May 20, 2015 00:00

Roche Global Biostatistics Conference (contributed talk)

Bayesian predictive power: update after a blinded interim and fallacies

Apr 17, 2015 00:00

Seminar, Institute for Mathematical Statistics and Actuarial Science, University of Bern (invited talk)

2014

How good is your biomarker? Comparison of development plans for confirmatory biomarker enrichment

Nov 20, 2014 00:00

2nd BIMIT (Verbundprojekt Biostatistische Methoden zur effizienten Evaluation von Individualisierten Therapien) workshop (invited talk)

How good is your biomarker? Comparison of development plans for confirmatory biomarker enrichment

Nov 11, 2014 00:00

Joint DIA/AEMPS Statistics Workshop (invited talk)

How statistics can contribute to innovative trials

Sep 18, 2014 00:00

2nd Symposium for the RxDx Generation, Roche (invited talk)

Weibull Regression for a Right-Censored Endpoint with a Censored Covariate

Aug 28, 2014 00:00

Annual Conference of the International Society for Clinical Biostatistics (contributed talk)

Update Bayesian predictive power after a blinded interim analysis

Jul 2, 2014 00:00

Bayesian Biostatistics 2014 - Satellite conference of the International Biometric Conference (contributed talk)

Update Bayesian predictive power after a blinded interim analysis

Mar 27, 2014 00:00

University of Zurich / ETH applied statistics seminar (invited talk)

2013

Update Bayesian Predictive Power after a blinded interim analysis

Oct 23, 2013 00:00

Roche Global Biostatistics Conference (contributed talk)

2011

A smooth ROC curve estimator based on log-concave density estimates

Sep 13, 2011 00:00

Conference of the Central European Network of the International Biometric Society (CEN 2011, contributed talk)

Selection models with monotone weight functions in meta analysis

Jun 21, 2011 00:00

Methods in Meta Analysis Meeting (contributed talk)

2010

Ordered Monotone Regression

Aug 3, 2010 00:00

Joint Statistical Meetings (contributed talk)

Proposal of the vote of thanks in discussion of Cule, M., Samworth, R., and Stewart, M.: Maximum likelihood estimation of a multidimensional logconcave density

May 12, 2010 00:00

Research Section Meeting Royal Statistical Society (invited talk)

Ordered Monotone Regression

Mar 2, 2010 00:00

German Open Conference on Probability and Stochastics (contributed talk)

Score regression: a new approach to assess calibration of continuous probabilistic predictions

Jan 26, 2010 00:00

Workshop Statistical Issues in Prediction: What can be Learned for Individualized Predictive Medicine? (invited talk)

Ordered monotone regression

Jan 12, 2010 00:00

Seminar, Basel Biometric Section of the IBS (invited talk)

2009

Regularized regression models in R

Feb 11, 2009 00:00

Department of Neurology and Neurological Sciences, Stanford University School of Medicine (invited talk)

2008

On a new approach to regression models with ordinal explanatory variables

Mar 12, 2008 00:00

Conference of the Central European Network of the International Biometric Society (Lifestat 2008, contributed talk)

A general criterion for multiscale inference

Jan 17, 2008 00:00

Seminar, Basel Biometric Section of the IBS (invited talk)

2007

Nonparametric Estimation of Log-Concave Densities

Dec 8, 2007 00:00

Seminar, Institute for Stochastics, University of Karlsruhe (invited talk)

A general criterion for multiscale inference

Sep 28, 2007 00:00

Seminar, Institute for Mathematical Statistics and Actuarial Science, University of Bern (invited talk)

Predicting Alzheimer from proteomic blood markers

Sep 13, 2007 00:00

Basel Institute for Clinical Epidemiology, University of Basel (invited talk)

On a new approach to regression with ordered explanatory variables

Sep 11, 2007 00:00

Conference of the Austro-Swiss Region of the IBS (contributed talk)

Max-domain of attraction for log-concave densities and smooth tail index estimation

Jul 31, 2007 00:00

Seminar, Statistics Department, Stanford University (invited talk)

2006

The log-concave density estimator as a smoother

Nov 11, 2006 00:00

Workshop Qualitative Assumptions and Regularization in High-Dimensional Statistics (invited talk)

Smoothed semi-parametric tail index estimation and max-domain of attraction for log-concave densities

Mar 15, 2006 00:00

German Open Conference on Probability and Stochastics (contributed talk)

2005

Log-concave density estimation

Aug 23, 2005 00:00

Seminar, Statistics Department, Stanford University (invited talk)

Log-concave density estimation

Jul 27, 2005 00:00

European Meeting of Statisticians (contributed talk)

Log-concave density estimation and bump hunting

Jul 19, 2005 00:00

European Young Statisticians Training Camp (contributed talk)

2004

Log-concave density estimation and uniform rate of convergence

Mar 26, 2004 00:00

German Open Conference on Probability and Stochastics (contributed talk)

2003

Computing maximum likelihood estimators of log-concave densities

Aug 6, 2003 00:00

Joint Statistical Meetings (contributed talk)