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Kaspar Rufibach
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Talks
2020
Use of multistate models to improve decision-making in clinical trials
Dec 9, 2020 09:15
Seminar, Vienna Biometric Section (invited talk)
Slides
Estimands update: Summary of world-wide authority interaction
Nov 27, 2020 00:00
Meeting of the Working Group Pharmaceutical Research of the German Region of the IBS
A deep dive into principal stratification and causal inference
Nov 17, 2020 00:00
Effective statistician podcast (invited discussion jointly with Björn Bornkamp)
Video
Use of multistate models to improve decision-making in clinical trials
Oct 21, 2020 11:00
Seminar, Department of Mathematics, University of Basel (invited talk)
PSI Conference Webinar: Impact of COVID-19 to estimands
Jun 11, 2020 15:30
PSI webinar (invited talk)
Slides
Panel discussion: estimands in oncology
May 21, 2020 17:00
Virtual panel discussion (invited talk)
Slides
Video
Use of multistate models to improve decision-making in clinical trials
Feb 28, 2020 16:15
University of Zurich / ETH applied statistics seminar (invited talk)
A statistician's view on complex innovative designs
Feb 25, 2020 10:15
Workshop
Complex Adaptive Clinical Trials
swissethics - Swissmedic (invited talk)
2019
Use of multistate models to jointly model progression-free and overall survival and improve decision-making in clinical trials
Nov 14, 2019 14:00
Seminar, MRC Biostatistics Unit, Cambridge University (invited talk)
Slides
Implications of the ICH E9 estimand addendum on how we develop, run, and analyze clinical trials
Oct 16, 2019 11:25
Clinical Trials Europe (invited talk)
Slides
Before going BIG - seize opportunities for small data: use of multistate models to improve decision-making and effect quantification in clinical trials
Sep 10, 2019 15:10
Conference of the Austro-Swiss Region of the IBS (invited talk)
PDF
Slides
Code
rpact - R Package for Adaptive Clinical Trials
Jul 4, 2019 15:00
PSI webinar (invited talk)
Slides
Multistate models to improve decision-making and effect quantification in clinical trials
Jun 27, 2019 00:00
Shanghai Biostatistics Forum (invited talk)
Estimand framework in Oncology drug development – impact and opportunities
Jun 4, 2019 00:00
PSI annual conference (contributed talk)
Bayesian Predictive Power: Theory, challenges in implementation, and perspectives
May 23, 2019 00:00
Bayesian Biostatistics Conference (bayes-pharma, invited talk)
PDF
External controls in drug development (with Hans Ulrich Burger)
May 10, 2019 00:00
Spring seminar of the Basel Biometric Section (invited talk)
PDF
MIRROS: Phase 3 trial with time-to-event endpoint, cure proportion, and futility interim analysis using response
Apr 2, 2019 00:00
SMi conference on adaptive clinical trials (invited talk)
Slides
Estimand framework in Oncology drug development -- impact and opportunities
Mar 19, 2019 00:00
Annual Meeting of the International Biometric Society, German Region (contributed talk delivered by Bjoern Bornkamp)
2018
Univariate log-concave density estimation and more efficient treatment effect estimation in pre-specified subgroups displayed in forest plots for time-to-event outcomes
Nov 22, 2018 00:00
Statistics seminar, University of Bochum (invited talk)
MIRROS: Planning a Phase 3 trial with time-to-event endpoint, a cure proportion, and a futility interim analysis using response
Oct 23, 2018 00:00
Oncology workshop, University of Heidelberg (invited talk)
Randomization and External Controls - When to Use What in a Drug Development Landscape
Oct 18, 2018 00:00
Roche RxDx summit (invited talk)
Assess Common Surrogate Endpoints in Lymphoma using a Multistate Model
Oct 17, 2018 00:00
Roche Global Biostatistics Conference (contributed talk)
More efficient treatment effect estimation in pre-specified subgroups displayed in forest plots for time-to-event outcomes
Oct 4, 2018 00:00
Workshop on Adaptive Designs and Multiple Testing Procedures (contributed talk)
Immortal bias - you live longer if you cannot die
Sep 10, 2018 00:00
Modeling and Simulation seminar (invited talk)
Slides
Overall survival prediction conditional on post-randomization events: multistate models, landmark analyses, and others
Jun 21, 2018 00:00
Seminar Biostatistics group Boehringer-Ingelheim (invited talk)
The Estimand Framework Applied to Time-to-event Endpoints
Mar 28, 2018 00:00
Annual Meeting of the International Biometric Society, German Region (contributed talk)
Estimands and the ICH E9 draft addendum
Feb 13, 2018 00:00
Special Colloquia Epidemiology, Biostatistics, and Prevention Institute, University of Zurich (invited talk)
2017
Treatment effect measures for time-to-event endpoints - estimands, analysis strategies, and beyond
Nov 24, 2017 00:00
Meeting of the Working Group Pharmaceutical Research of the German Region of the IBS (invited talk)
Construction of an Estimand in a Clinical Trial on Progressive Multiple Sclerosis
Oct 4, 2017 00:00
2nd EFSPI Regulatory Statistics Workshop (invited talk)
PDF
Evolvement of assurance over the lifecycle of several Phase 3 trials in a large oncology clinical development program
Aug 31, 2017 00:00
Joint Meeting of the International Biometric Society Austro-Swiss, German, and Polish Region (invited talk)
Joint modelling of progression-free and overall survival
Jul 12, 2017 00:00
Annual Conference of the International Society for Clinical Biostatistics (contributed talk)
Treatment effect measures for time-to-event endpoints - Estimands and beyond
Jun 13, 2017 00:00
Workshop on Innovation in Oncology Clinical Trial Design, organized by the Cancer Drug Development Forum (invited talk)
PDF
Comparison of clinical development plans for a confirmatory trial with subpopulation selection
Mar 13, 2017 00:00
Seminar, Basel Biometric Section of the IBS (invited talk)
PDF
2016
Bayesian Predictive Power: update after a blinded interim analysis and choice of update after a blinded interim analysis and choice of prior
Dec 12, 2016 00:00
Statistics Seminar, Institute for Medical Biometry, University of Heidelberg (invited talk)
Estimands for time to event endpoints
Nov 14, 2016 00:00
European Statistical Forum (invited talk)
Bayesian Predictive Power: update after a blinded interim analysis and choice of prior
Nov 10, 2016 00:00
Statistics Seminar, Institute for Social and Preventive Medicine, University of Lausanne (invited talk)
Estimands for time to event endpoints in oncology and beyond
Sep 12, 2016 00:00
1st EFSPI Regulatory Statistics Workshop (invited talk, delivered by Uli Burger)
PDF
Bayesian Predictive Power: Choice of Prior and some implications
Aug 23, 2016 00:00
Annual Conference of the International Society for Clinical Biostatistics (contributed talk)
Bayesian Predictive Power: Choice of Prior and some Recommendations for its Use as Probability of Success in Drug Development
May 24, 2016 00:00
PSI annual conference (contributed talk delivered by Markus Abt)
Time to think about estimands for time-to-event endpoints? A few examples
May 24, 2016 00:00
PSI conference (invited talk, delivered by Uli Burger)
Event projection: quantify uncertainty and manage expectations of broader teams
Apr 28, 2016 00:00
Seminar, Basel Biometric Section of the IBS (invited talk)
PDF
Bayesian Predictive Power: Choice of Prior and some Recommendations for its Use as Probability of Success in Drug Development
Mar 2, 2016 00:00
Statistics Seminar, University of Ulm (invited talk)
2015
A Weibull Regression Model for a Time-to-Event Endpoint with an Interval-Censored Covariate and its Application in Assessing Prentice's Criteria for Surrogacy
Nov 20, 2015 00:00
3rd BIMIT (Verbundprojekt
Biostatistische Methoden zur effizienten Evaluation von Individualisierten Therapien
) workshop (invited talk)
Bayesian Predictive power: the bathtub phenomenon
Oct 27, 2015 00:00
Seminar, Basel Biometric Section of the IBS (invited talk)
Comparison of clinical development plans for a confirmatory trial with subpopulation selection
Jun 18, 2015 00:00
Joint Meeting of the International Biometric Society Austro-Swiss and Italian Regions (invited talk)
Evaluation of possible designs for a three-arm clinical trial: Comparing a closed-testing design to potential alternatives
Jun 16, 2015 00:00
Joint Meeting of the International Biometric Society Austro-Swiss and Italian Regions (contributed talk)
Evaluation of possible designs for a three-arm clinical trial: Comparing the CLL11 design to potential alternative designs
May 20, 2015 00:00
Roche Global Biostatistics Conference (contributed talk)
Bayesian predictive power: update after a blinded interim and fallacies
Apr 17, 2015 00:00
Seminar, Institute for Mathematical Statistics and Actuarial Science, University of Bern (invited talk)
2014
How good is your biomarker? Comparison of development plans for confirmatory biomarker enrichment
Nov 20, 2014 00:00
2nd BIMIT (Verbundprojekt
Biostatistische Methoden zur effizienten Evaluation von Individualisierten Therapien
) workshop (invited talk)
How good is your biomarker? Comparison of development plans for confirmatory biomarker enrichment
Nov 11, 2014 00:00
Joint DIA/AEMPS Statistics Workshop (invited talk)
How statistics can contribute to innovative trials
Sep 18, 2014 00:00
2nd Symposium for the RxDx Generation, Roche (invited talk)
Weibull Regression for a Right-Censored Endpoint with a Censored Covariate
Aug 28, 2014 00:00
Annual Conference of the International Society for Clinical Biostatistics (contributed talk)
Update Bayesian predictive power after a blinded interim analysis
Jul 2, 2014 00:00
Bayesian Biostatistics 2014 - Satellite conference of the International Biometric Conference (contributed talk)
Update Bayesian predictive power after a blinded interim analysis
Mar 27, 2014 00:00
University of Zurich / ETH applied statistics seminar (invited talk)
2013
Update Bayesian Predictive Power after a blinded interim analysis
Oct 23, 2013 00:00
Roche Global Biostatistics Conference (contributed talk)
2011
A smooth ROC curve estimator based on log-concave density estimates
Sep 13, 2011 00:00
Conference of the Central European Network of the International Biometric Society (CEN 2011, contributed talk)
Selection models with monotone weight functions in meta analysis
Jun 21, 2011 00:00
Methods in Meta Analysis Meeting (contributed talk)
2010
Ordered Monotone Regression
Aug 3, 2010 00:00
Joint Statistical Meetings (contributed talk)
Proposal of the vote of thanks in discussion of Cule, M., Samworth, R., and Stewart, M.: Maximum likelihood estimation of a multidimensional logconcave density
May 12, 2010 00:00
Research Section Meeting Royal Statistical Society (invited talk)
Ordered Monotone Regression
Mar 2, 2010 00:00
German Open Conference on Probability and Stochastics (contributed talk)
Score regression: a new approach to assess calibration of continuous probabilistic predictions
Jan 26, 2010 00:00
Workshop
Statistical Issues in Prediction: What can be Learned for Individualized Predictive Medicine?
(invited talk)
Ordered monotone regression
Jan 12, 2010 00:00
Seminar, Basel Biometric Section of the IBS (invited talk)
2009
Regularized regression models in R
Feb 11, 2009 00:00
Department of Neurology and Neurological Sciences, Stanford University School of Medicine (invited talk)
2008
On a new approach to regression models with ordinal explanatory variables
Mar 12, 2008 00:00
Conference of the Central European Network of the International Biometric Society (Lifestat 2008, contributed talk)
A general criterion for multiscale inference
Jan 17, 2008 00:00
Seminar, Basel Biometric Section of the IBS (invited talk)
2007
Nonparametric Estimation of Log-Concave Densities
Dec 8, 2007 00:00
Seminar, Institute for Stochastics, University of Karlsruhe (invited talk)
A general criterion for multiscale inference
Sep 28, 2007 00:00
Seminar, Institute for Mathematical Statistics and Actuarial Science, University of Bern (invited talk)
Predicting Alzheimer from proteomic blood markers
Sep 13, 2007 00:00
Basel Institute for Clinical Epidemiology, University of Basel (invited talk)
On a new approach to regression with ordered explanatory variables
Sep 11, 2007 00:00
Conference of the Austro-Swiss Region of the IBS (contributed talk)
Max-domain of attraction for log-concave densities and smooth tail index estimation
Jul 31, 2007 00:00
Seminar, Statistics Department, Stanford University (invited talk)
2006
The log-concave density estimator as a smoother
Nov 11, 2006 00:00
Workshop
Qualitative Assumptions and Regularization in High-Dimensional Statistics
(invited talk)
Smoothed semi-parametric tail index estimation and max-domain of attraction for log-concave densities
Mar 15, 2006 00:00
German Open Conference on Probability and Stochastics (contributed talk)
2005
Log-concave density estimation
Aug 23, 2005 00:00
Seminar, Statistics Department, Stanford University (invited talk)
Log-concave density estimation
Jul 27, 2005 00:00
European Meeting of Statisticians (contributed talk)
Log-concave density estimation and bump hunting
Jul 19, 2005 00:00
European Young Statisticians Training Camp (contributed talk)
2004
Log-concave density estimation and uniform rate of convergence
Mar 26, 2004 00:00
German Open Conference on Probability and Stochastics (contributed talk)
2003
Computing maximum likelihood estimators of log-concave densities
Aug 6, 2003 00:00
Joint Statistical Meetings (contributed talk)
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