Overall survival prediction conditional on post-randomization events: multistate models, landmark analyses, and others


The proportion of patients with progression at 24 months or complete response at 30 months are considered potential surrogate endpoints for overall survival (OS) in first line follicular lymphoma. I explore OS predictions conditional on a patient’s status at 24 or 30 months based on a multistate model applied to data of a pivotal Phase 3 trial and discuss some connections of multistate models over alternatives.

Seminar Biostatistics group Boehringer-Ingelheim (invited talk)
Biberach, Germany