I will illustrate how critical decisions in drug development are typically based on a tiny fraction of the collected data only. As an example, in early development oncology clinical trials, the decision whether to move a molecule to Phase 3 is typically based on response proportions and duration of response in those that respond, while in Phase 3 the primary endpoint will be long-term endpoints such as PFS or OS. Effects on response-based short-term endpoints seldom translate in effects on these relevant endpoints. We propose to make decisions not based on intermediate endpoints, but on a prediction of the OS hazard ratio (HR) between data of the new molecule collected in the early phase trial and historical data of the control treatment. This HR prediction is using a multistate model based on the various disease states a patient may go through until death. This yields a gating strategy with improved operating characteristics compared to traditional decision rules in the context of early phase clinical trials.
The main conclusion of this talk is that multistate models are a useful and underutilized tool in the analysis of clinical trial data.
This is joint work with Ulrich Beyer, David Dejardin, Matthias Meller, and Uli Burger.