A deep dive into principal stratification and causal inference


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Principal stratification used to play a role only in observational research but at least since the addendum of the ICH E9 guideline, this approach to causal inference became a hot topic.

We cover the following questions:

  • What is Principal Stratification?
  • How would you describe principal stratification to a non-statistician?
  • Where do you see the benefits of this estimand compared to the other typical strategies?
  • Which critique points do are usually raised against this approach?
  • How do you implement/calculate corresponding estimates for this estimand?
  • What references would you recommend for further reading?